At the Faculty of Biology of Baku State University (BSU), Aykhan Yusifov, a graduate of the faculty, researcher at the University of Wyoming, USA, Doctor of Philosophy, held a scientific seminar on "Age and gender differences in the changes that occur during heart failure".
The speaker explained how a sharp increase in the amount of catecholamines in the blood occurs during heart failure. He said that catecholamines bind to Adrenergic Receptors (AR) in the heart and lead to heart failure. In the medical field, the harmful effects of overstimulation of the AR have been studied in detail. Administration of AR-blocking drugs, β-blockers in the treatment process to young and old patients, including women, in the same doses leads to different results. Age- and gender-specific differences in AR activation need to be elucidated to learn the scientific basis of these different results. To investigate these differences, Aykhan Yusifov told the audience that he studied AR activation in a rodent model using the drug isoproterenol (ISO) and applied this drug to juvenile (4 weeks old), middle-aged (4-6 months) and old (18 months) C57Bl6 mice, both female and male. delivered. As a result of scientific research, age and gender differences were observed in the expression of β-AR genes, kinase (kinase) activity and phosphorylation of myofilament proteins. At an early age, sports activities create such changes in the heart that years later, due to these changes, the heart can cope with stress at a higher level.

In the end, the speaker answered many questions of the participants.